Morphing Neural Interface
Morphing electronics technology can enable longitudinal interrogation of the electrophysiological-neurochemical dynamics during network formation in developing nervous system, beyond the mature nervous system. We aim to develop new tools that interface with single neurons throughout the developmental phase to advance the study of neural circuit formation and neuronal diseases.
Morphing electronics enable neuromodulation in growing tissue. Nature Biotechnology 2020.
Morphing bioelectronics. Nature Portfolio Bioengineering Community, 2020
Living Bioelectronics Medicine
We aim to develop precision electronic medicine to treat autoimmune and metabolic diseases through organ-specific, personalized neuromodulation, informed by feedback from interoceptive signals. Our goal is to use “electrons” instead of “molecules” (pharmaceuticals) to precisely modulate “inflammatory reflex” with high temporospatial resolution. We are developing a “living intelligence layer” that symbiotically integrates with the human body.
A tissue-like neurotransmitter sensor for the brain and gut, Nature, 2022
Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation, Nature Biomedical Engineering, 2019
Medical Wearable Electronics
Wearable health monitoring is limited by biofluid accessibility, motion artifacts, and biosignal bandwidth. We are developing solid-state epidermal biomarker sensing, which detects multiple solid molecular residues naturally present on the skin surface without relying on sweat collection or invasive biofluid sampling. This universal wearable platform enables real-time monitoring of metabolic and cardiovascular biomarkers for population-scale screening and preventive medicine. Our goal is to reduce the invasive blood tests with our solid-state epidermal biomarker sensing technology.